If you like a tender, lightly sweet loaf that works for breakfast or an afternoon snack, this Blueberry Cream Cheese Bread fits right in. It’s a simple quick bread with a soft crumb, dotted with juicy blueberries, and a gentle ribbon of tangy cream cheese through the middle. Nothing flashy, nothing fussy. Just a cozy slice that feels at home with a mug of coffee or a glass of cold milk. Take a breath, preheat the oven, and let’s bake.

Ingredients for this Blueberry Cream Cheese Bread

For the bread:

2 cups all-purpose flour (240 g), plus 1 tablespoon for the berries
1 cup granulated sugar (200 g)
2 teaspoons baking powder
1/2 teaspoon fine salt
2 large eggs, room temperature
1/2 cup neutral oil, like canola or light olive (120 ml)
1/2 cup milk (120 ml), room temperature
1/2 cup sour cream or plain Greek yogurt (120 g)
1 teaspoon vanilla extract
1 teaspoon finely grated lemon zest
1 1/2 cups fresh blueberries (about 225 g), or frozen, unthawed

For the cream cheese ribbon:

8 ounces cream cheese, softened (226 g)
1/4 cup granulated sugar (50 g)
1 egg yolk
1 teaspoon vanilla extract
1 tablespoon lemon juice
1 tablespoon cornstarch

Optional lemon glaze:

1/2 cup powdered sugar (60 g)
1 to 2 tablespoons lemon juice or milk, to thin

Instructions

Prep the pan. Heat the oven to 350°F, 175°C. Grease a 9 x 5 inch loaf pan and line it with a strip of parchment that hangs over the long sides for easy lifting later. A quick spritz on the parchment helps too.
Make the cream cheese ribbon. In a medium bowl, beat the cream cheese until smooth. Add sugar, egg yolk, vanilla, lemon juice, and cornstarch. Mix until creamy and lump free. Set aside. If it looks a touch loose, give it a minute to sit while you make the batter, it will thicken slightly.
Mix the dry ingredients. In a large bowl, whisk together flour, sugar, baking powder, and salt. A minute of whisking saves you from sifting, and it aerates the mixture a bit.
Mix the wet ingredients. In a separate bowl or large measuring cup, whisk the eggs, oil, milk, sour cream, vanilla, and lemon zest until smooth. It should look uniform, no streaks.
Combine. Pour the wet mixture into the dry. Stir gently with a spatula until just combined. A few small flour streaks are okay. Overmixing leads to a tougher loaf, so keep it chill.
Fold in berries. Toss the blueberries with 1 tablespoon flour, especially if using fresh berries. This helps them hold in place. Fold 1 cup of the berries into the batter. Save the remaining 1/2 cup for the top.
Layer the loaf. Spoon about half the batter into the prepared pan and smooth it. Dollop the cream cheese mixture over the batter in a thick ribbon, leaving a small border at the edges. Spoon the remaining batter on top in gentle mounds, then spread to cover. Sprinkle the remaining berries over the top and lightly press them in so they are just nestled, not buried.
Bake. Set the pan on the middle rack and bake for 55 to 65 minutes, until the top is golden and a toothpick inserted into the bread part (avoid the cream cheese) comes out with a few moist crumbs. If the loaf is browning quickly, tent loosely with foil at the 45 minute mark. A kitchen will smell like blueberry pie by then, which is always a good sign.
Cool. Let the bread rest in the pan for 15 minutes. Use the parchment to lift it out and set it on a wire rack to cool completely, about 1 hour. The cream cheese needs that time to set fully, so try not to rush it. I know, the wait is the hardest part.
Glaze, if you like. Stir powdered sugar with lemon juice or milk until smooth and pourable. Drizzle over the cooled loaf. Slice with a sharp serrated knife for neat pieces.

Cook and Prep Times

Prep time: 20 minutes
Bake time: 55 to 65 minutes
Cooling time: 60 minutes
Total time: about 2 hours 15 minutes

Nutritional information

Approximate per slice, based on 12 slices and without glaze:

Calories: 320
Total fat: 14 g
Saturated fat: 6 g
Carbohydrates: 44 g
Fiber: 1 g
Sugars: 26 g
Protein: 5 g
Sodium: 230 mg

These are estimates and will vary with ingredient brands and portion size. If you add the glaze, plan on about 20 to 25 extra calories per slice.

Frequently asked questions

Can I use frozen blueberries?

Yes. Use them straight from the freezer, do not thaw. Toss lightly with the tablespoon of flour, fold them in gently, and expect the batter to look a little streaky purple. That’s normal. Add 3 to 5 minutes to the bake time if needed, and check for doneness as usual. If the top is browning before the center sets, tent with foil for the last stretch.

How should I store Blueberry Cream Cheese Bread?

Once fully cool, wrap the loaf snugly or store slices in an airtight container. It keeps at room temperature for 1 day, then move to the fridge for up to 4 days. The cream cheese layer stays safest chilled. For longer storage, freeze individual slices, well wrapped, for up to 2 months. Thaw at room temperature or overnight in the fridge, then warm gently in a low oven or toaster oven to refresh.

Why did my loaf sink or crack on top?

A slight crack is okay and common with quick breads. A deep collapse usually means the center was underbaked, the oven door was opened early, or the batter was overmixed. Another culprit is the cream cheese ribbon bulking up in one heavy layer. To help prevent issues, measure flour accurately, mix until just combined, try not to peek for the first 40 minutes, and test doneness in multiple spots. If your oven runs cool, baking can stretch longer than expected, so an oven thermometer is handy.