If you love pizza night but don’t always feel like rolling out dough or ordering in, this Bubble Up Biscuit Pizza Casserole is a nice middle ground. It has all the familiar flavors of a classic pizza, but everything is baked together in one pan with soft, fluffy biscuit pieces that “bubble up” through the sauce and cheese. It’s simple, cozy, and very weeknight-friendly.

This Bubble Up Biscuit Pizza Casserole starts with browned ground beef, plenty of pizza sauce, and a can of refrigerated biscuit dough. The biscuit pieces soak up the sauce as they bake, while mozzarella, a bit of cheddar, pepperoni, and some diced green bell pepper and red onion melt together on top. It feels like a cross between a deep-dish pizza and a hearty casserole, which is exactly the kind of meal that tends to disappear fast from the table.

Ingredients for this Bubble Up Biscuit Pizza Casserole

Before you preheat the oven, it helps to have everything ready to go. Here’s what you’ll need for this Bubble Up Biscuit Pizza Casserole:

1 lb ground beef – This gives the casserole a satisfying, meaty base. Browning it first adds flavor and helps it hold up well with the sauce and biscuits.
2 cups pizza sauce – Use your favorite brand or style. This coats the biscuit pieces and keeps everything moist as it bakes.
1 can refrigerated biscuit dough (16 oz, large flaky-style biscuits) – The star of the “bubble up” effect. The biscuit pieces puff up through the sauce and cheese in the oven.
2 cups shredded mozzarella cheese – For that classic stretchy, melty pizza topping.
1/2 cup shredded cheddar cheese – Adds a little extra richness and a slightly sharper flavor on top.
1/2 cup sliced pepperoni – Scattered over the top for that familiar pizza taste.
1/2 cup diced green bell pepper – Brings a bit of color and crunch to balance the richness.
1/4 cup diced red onion – Adds a mild bite that works well with the beef and cheese.
1 tsp dried Italian seasoning – A simple blend that gives the sauce a more homemade feel.
1/2 tsp garlic powder – For gentle garlic flavor without extra chopping.
1/2 tsp salt – Seasons the beef and sauce. You can adjust slightly to taste.
1/4 tsp black pepper – A small touch of warmth and depth.
1 tbsp olive oil (for greasing the baking dish) – Helps keep the bottom from sticking and makes serving easier.

Once everything is measured out, the actual hands-on time is pretty short. Most of the magic happens in the oven while you tidy up the kitchen or set the table.

Instructions

Here’s how to bring this Bubble Up Biscuit Pizza Casserole together, step by step.

Preheat and prepare the pan.
Set your oven to 375°F (190°C). While it warms up, lightly grease a 9×13-inch baking dish with the olive oil. Just a thin coating is enough to help prevent sticking and makes it easier to scoop out neat portions later.
Brown the ground beef.
Place a large skillet over medium-high heat and add the ground beef. Cook it for about 6–8 minutes, breaking it up with a spatula as it browns. You want it fully cooked, with no pink remaining. If you’ve ever stood at the stove, absentmindedly stirring while thinking about your day, that’s exactly the mood here — low effort, simple cooking.
Drain and season.
When the beef is browned, carefully drain off any excess fat from the skillet. Return the beef to medium heat and stir in the pizza sauce, dried Italian seasoning, garlic powder, salt, and black pepper. Let this mixture simmer for 2–3 minutes, just until it’s warmed through and the flavors have a moment to come together. Then remove the skillet from the heat.
Cut the biscuit dough.
Open the can of refrigerated biscuit dough and separate the biscuits. Using a sharp knife or kitchen scissors, cut each biscuit into 6 to 8 small pieces. They don’t have to be perfect; roughly bite-sized pieces are ideal. These little chunks are what will puff up and peek through the cheese as the casserole bakes.
Combine biscuits with the beef and sauce.
Add the biscuit pieces directly into the skillet with the warm beef and pizza sauce mixture. Gently fold everything together so the biscuit pieces are evenly coated in sauce. Take your time here; you want each piece to get some sauce so it doesn’t dry out in the oven.
Transfer to the baking dish.
Pour the biscuit and beef mixture into your prepared 9×13-inch baking dish. Spread it out in an even layer, nudging the biscuit pieces so they’re fairly evenly distributed. This helps the casserole bake more uniformly, with little pockets of biscuit throughout.
Add the vegetables.
Sprinkle the diced green bell pepper and diced red onion evenly over the top of the biscuit mixture. You’ll see pops of green and purple here and there, which not only look nice but also add a bit of freshness to each bite.
Layer on the pepperoni.
Scatter the sliced pepperoni over the vegetables. Try to distribute it so each scoop of casserole will have a few slices. This step always feels a little like decorating a pizza — no need for perfection, just make sure the top is dotted with pepperoni.
Top with cheese.
Sprinkle the shredded mozzarella cheese evenly over the casserole, followed by the shredded cheddar cheese. The mozzarella gives you that classic melt, while the cheddar adds a touch of color and extra flavor. At this point, it already looks pretty good, even before it hits the oven.
Bake until bubbly and golden.
Place the baking dish in the preheated oven and bake for 25–30 minutes. You’ll know it’s done when the biscuits have puffed up through the sauce and cheese, and the top is melted and lightly golden in spots. If you gently nudge the center with a spoon, it should feel set, not doughy.
Rest and serve.
Remove the Bubble Up Biscuit Pizza Casserole from the oven and let it sit for about 5–10 minutes. This short rest helps the casserole firm up a bit so it’s easier to slice and serve. Then cut into portions and serve warm. It’s one of those dishes that brings everyone to the table quickly, especially when they catch that pizza smell drifting from the oven.

Cook and Prep Times

Prep time: 15 minutes
Cook time: 30 minutes
Total time: About 45 minutes
Servings: Approximately 6 portions

Nutritional information

The numbers below are an estimate per serving, assuming the casserole is divided into six portions. They can vary a bit depending on the specific brands of ingredients you use, especially the pizza sauce, cheese, and biscuit dough.

Calories: 520 kcal
Carbohydrates: 34 g
Protein: 27 g
Fat: 30 g
Saturated fat: 13 g
Sodium: 1180 mg
Fiber: 2 g
Sugar: 7 g

This Bubble Up Biscuit Pizza Casserole is definitely more of a comfort food than a light meal, but it does bring a decent amount of protein from the ground beef and cheese. If you like, you can pair it with a simple side salad or some steamed vegetables to round out the plate.

Frequently asked questions

Can I make this Bubble Up Biscuit Pizza Casserole ahead of time?

You can do a bit of prep in advance. Brown the ground beef, stir in the pizza sauce, Italian seasoning, garlic powder, salt, and black pepper, then let the mixture cool and store it in the fridge. When you’re ready to bake, cut the refrigerated biscuit dough into pieces, fold them into the chilled beef and sauce, transfer everything to the greased baking dish, add the green bell pepper, red onion, pepperoni, and cheeses, and bake as directed. It’s best to wait to add the biscuit pieces until just before baking so they rise properly.

How do I store and reheat leftovers?

Let any leftover Bubble Up Biscuit Pizza Casserole cool to room temperature, then transfer it to an airtight container or cover the baking dish tightly. Store it in the refrigerator for up to 3 days. To reheat, warm individual portions in the microwave until hot, or place the baking dish back in a 350°F (175°C) oven until heated through. The biscuits will soften a bit as they sit, but the flavors are still very comforting the next day.

Can I change the toppings in this casserole?

You can absolutely adjust the toppings within the ingredients you already have here. For example, you can use a little more or less pepperoni, or adjust the amounts of green bell pepper and red onion to suit your taste. The base of ground beef, pizza sauce, refrigerated biscuit dough, and the cheeses is quite flexible, so it handles those small tweaks easily while keeping the same overall feel of a Bubble Up Biscuit Pizza Casserole.

Read this recipe out loud once if you can — it should feel like someone is just walking you through dinner plans, step by step, without any fuss. That’s exactly the idea behind this Bubble Up Biscuit Pizza Casserole: simple ingredients, straightforward steps, and a warm, filling meal at the end.